Driving Discoveries – Accelerating Research blog by Maria Kaisar, Associate Professor of Transplantation Science, University of Oxford and QUOD Basic Science Coordinator

Kidney Research UK’s annual research conference, Driving Discoveries – Accelerating Research, has evolved to be one of the highlights in our scientific diaries. This year’s conference was no exception, in that it was an excellent congregation of scientists and early career researchers who showcased the ongoing novel and impactful scientific work in kidney disease, funded by Kidney Research UK.  This year’s conference also introduced a new initiative where each session was chaired by an academic and a patient, so Professor Claire Sharpe and patient co-chair, Ifrah Raza chaired the opening session ‘Making discoveries count: the pathway to patients’ in which I had been invited, alongside Professor Nick Selby, to give a talk.

My talk ‘Improving donor kidney assessment developing new therapies so transplants last for longer’ covered research updates on our two research projects funded by KRUK, known as ADMIRE ‘Assessing Donor Kidneys and Monitoring Transplant REcipients and REDEEM ‘REnal Degradomics – Examining Donor Kidney Extracellular Matrices’. I took this opportunity to describe our research on developing better markers to assess donor kidneys. Analysis of a large number of QUOD samples and the application of machine learning approaches shows that we can develop more accurate methods to assess donor organs so only the organs that will function well are transplanted. I was also very happy to show our data on better understanding the biological processes of kidney injury and repair and how we could use targeted therapies to either protect donor organs from further injury during donor management or during preservation. I also presented our collaborative work on the potential use of MRI to assess donor organs and monitor transplant recipients led by Professor Sue Francis at Nottingham University, who was also one of the attendees.

Since members from my team also attended the conference, we had opportunities to socialise and meet other researchers at the poster sessions and over dinner. The Driving Discoveries – Accelerating Research meeting brings the kidney research community together to share their knowledge and speak about the work they are doing to improve the lives of kidney patients, so I am looking forward to next year’s highlights already!

Dr Maria Kaisar – Developing new ways to assess kidneys so transplants last for longer.

With funding from Kidney Research UK, a team of researchers from the University of Oxford, the University of Nottingham and University College London will develop ways to assess donor kidneys and predict how well they will work after transplant.

Having a kidney transplant is the best treatment for kidney failure, but the demand for donated kidneys is high.

To save more lives, doctors are now accepting kidneys from older or higher risk donors. These kidneys may also work less well after transplantation. This can have devastating effects, causing patients once recovering from transplantation to also go back on to dialysis, and wait for another transplant.

Right now, doctors cannot accurately assess donor kidneys. This makes it difficult to predict how well a transplant will work and how long a kidney will last after it has been transplanted.

Thanks to Kidney Research UK’s grant award of £237,626, (in partnership with the Stoneygate Trust), the ADMIRE study ‘Assessing Donor kidneys and Monitoring Transplant Recipients’ aims to address this clinical challenge.

Dr Maria Kaisar

Dr Maria Kaisar from Oxford University’s Nuffield Department of Surgical Sciences (NDS) is the Principal Investigator on the study and leads a team of co-investigators from NDS (Professor Rutger Ploeg, Dr Edward Sharples, Mr Simon KnightMr James Hunter and Dr Sadr Shaheed), the Oxford Big Data Institute (Dr Alberto Santos Delgado and Dr Philip Charles) and the Radcliffe Department of Medicine (Dr Elizabeth Tunnicliffe)

Dr Maria Kaisar and her team will utilise the Oxford Transplant Biobank (OTB) and the Quality in Organ Donation (QUOD) biobank to look for marker proteins in the donors’ blood samples. They use these samples to develop a mathematical model to predict how well donor kidneys will work after transplantation. The successful model would allow doctors to accurately assess kidneys and only transplant those that will function well. It could also identify suitable kidneys previously deemed too high risk to transplant.

With Professors Sue Francis and David Long from the University of Nottingham and University College London, the NDS team will use the QUOD X platform to also develop a monitoring strategy. MRI scanning methods will be performed on both the donor organ before it is transplanted, and later on after transplantation. This will allow us to monitor how well the transplanted organ is functioning.

“I am absolutely delighted that our study received this funding award by Kidney Research UK in partnership with The Stoneygate Trust,” said Maria. “This funding will enable us to bring scientific and clinical expertise together in collaboration, to develop novel non-invasive methods to better assess donor kidneys and, predict how well a transplant will work in the recipient. We also envisage that our planned scientific work will offer many opportunities to our early career scientists, to further develop their skills and research expertise in studying kidney disease. “