QUOD Publications and Presentations

QUOD biobank materials and data were used by research groups in studies that generated the following publications and presentations.

Did we miss one? Please let us know by emailing quod-research@nds.ox.ac.uk.

Publications

Kaisar M, van Dullemen L, Thézénas ML, Akhtar Z, Huang H, Rendel S, Charles P, Fischer R, Ploeg R, Kessler B
Plasma degradome affected by variable storage of human blood.
Clinical Proteomics 2016 (13:26).
DOI: 10.1186/s12014-016-9126-9

Khorsandi SE, Salehi S, Cortes M, Vilca-Melendez H, Menon K, Srinivasan P, Prachalias A, Jassem W, Heaton N.
An in silico argument for mitochondrial microRNA as a determinant of primary non function in liver transplantation.
Scientific Reports 2018 (8, art. 3105)
DOI: 10.1038/s41598-018-21091-9

Huang H, van Dullemen L, Akhtar MZ, Lo Faro ML, Yu Z, Valli A, Dona A, Thézénas ML, Charles P, Fischer R, Kaisar M, Leuvenink H.G. D., Ploeg R, Kessler B
Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion.
Scientific Reports 2018 (8, art. 8539)
DOI: 10.1038/s41598-018-26804-8

Chong S, Atkinson C, Banga N, Harber M, Reeves M, Magee, C
Association Between Donor/Recipient BK Viral Serostatus and Risk of BK Viraemia Post-Transplantation
Transplantation, 2018; 102: S567
DOI: 10.1097/01.tp.0000543438.89653.23

Jassem W, Xystrakis E, Ghnewa Y, Yuksel M, Pop O, Martinez-Llordella M, Jabri Y, Huang X, Lozano J, Quaglia A, Sanchez-Fueyo A, Coussios C, Rela M, Friend P, Heaton N, Ma Y
Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration
Hepatology, December 2018
DOI: 10.1002/hep.30475

Kaisar M, van Dullemen L, Charles P, Akhtar M, Thézénas M, Huang H, et al.
Subclinical Changes in Deceased Donor Kidney Proteomes are Associated with 12-month Allograft Function Post transplantation—a Preliminary Study.
Transplantation, 2019; 103: 323–328
DOI: 10.1097/TP.0000000000002358

White M, Maheshwari R, Anderson S, Berlinguer-Palmini R, Jones C, Richardson S, Rotti P, Armour S, Ding Y, Krasnogor N, Engelhardt J, Gray M, Morgan N, Shaw J.
In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas.
Journal of Endocrinology & Metabolism Nov. 2019.
DOI: 10.1210/clinem/dgz209

Presentations

Activated cytoprotective mechanisms in DBD kidneys correlate with kidney function in transplant recipients: A study using clinical samples from the UK QUOD biobank
M Kaisar, L van Dullemen, Z Akhtar, M Lo Faro, H Huang, H Leuvenink, B Kessler, R Ploeg
American Transplant Congress 2017
https://atcmeetingabstracts.com/abstract/activated-cytoprotective-mechanisms-in-dbd-kidneys-correlate-with-kidney-function-in-transplant-recipients-a-study-using-clinical-samples-from-the-uk-quod-biobank/

Proteomic profiles of donor kidney biopsies obtained at retrieval correlate to allograft function at 1 year post transplantation
Maria Kaisar, Leon V Dullemen, Zeeshan M Akhtar, Honglei Huang, Benedikt M Kessler, Rutger J Ploeg
Six of the Best: oral presentations, British Transplant Society 2017
https://bts.org.uk/wp-content/uploads/2017/03/BTS-Congress-2017-Abstract-Book.pdf

Metabolic dysregulation and mitochondrial dysfunction are key features of injury profiles of donor kidneys after brain and circulatory death
M Letizia Lo Faro, M Zeeshan Akhtar, Honglei Huang, Maria Kaisar, Rolando Rebolledo, Karl Morten, Lisa Heather, Anthony Dona, Henri Leuvenink, Susan Fuggle, Benedikt Kessler, Christopher Pugh, Rutger Ploeg
British Transplant Society 2017
https://bts.org.uk/wp-content/uploads/2017/03/BTS-Congress-2017-Abstract-Book.pdf

Pre-donation Serum NGAL to Assess the Quality of DBD and DCD Kidneys—A Pilot Study
Christopher Chalklin, Chantal Colmont, Soha Zouwail, Aeliya Zaidi, Elijah Ablorsu
British Transplant Society 2017
https://bts.org.uk/wp-content/uploads/2017/03/BTS-Congress-2017-Abstract-Book.pdf
https://www.morressier.com/article/predonation-serum-ngal-assess-quality-dbd-dcd-kidneys-pilot-study/58736690d462b8029238415d

Mitochondrial dysfunction is a common feature of injury in donor kidneys after brain and circulatory death
M Lo Faro, M Akhtar, H Huang, M Kaisar, R Rebolledo, K Morten, L Heather, A Dona, H Leuvenink, S Fuggle, B Kessler, C Pugh, R Ploeg
American Transplant Congress 2017
https://atcmeetingabstracts.com/abstract/mitochondrial-dysfunction-is-a-common-feature-of-injury-in-donor-kidneys-after-brain-and-circulatory-death/

Proteomic profiles of deceased donor kidney biopsies obtained prior to transplantation correlate with allograft function at one year
M Kaisar, L van Dullemen, Z Akhtar, H Huang, B Kessler, R Ploeg
American Transplant Congress 2017
https://atcmeetingabstracts.com/abstract/proteomic-profiles-of-deceased-donor-kidney-biopsies-obtained-prior-to-transplantation-correlate-with-allograft-function-at-one-year/

Association between donor:recipient BK viral serostatus and risk of BK viraemia post-transplantation
Stephanie Chong, Claire Atkinson, Neal Banga, Mark Harber, Matthew Reeves, Ciara N Magee
British Transplant Society 2018
https://bts.org.uk/wp-content/uploads/2018/03/Congress-Abstract-book-2018-9.03.18.pdf

Are there good and bad kidneys? A transcriptional approach
John Ferdinand, Patrick Trotter, Alexandra Riding, Kevin Loudon, Menna Clatworthy
British Transplant Society 2018
https://bts.org.uk/wp-content/uploads/2018/03/Congress-Abstract-book-2018-9.03.18.pdf

Initial Heart Tissue Collection Protocols for the MRC-Quality and Safety in Organ Donation Tissue Bank Expansion
MM Honkanen-Scott, J Doyle, S Rendel, M Bourne, Y Bury, D Tiniakos, R Ploeg, JAM Shaw, J Dark, WE Scott III
26th Northern Cardiovascular Research Group Meeting

Association between donor/recipient BK viral serostatus and risk of BK viraemia post-transplantation
S Chong, C Atkinson, N Banga, M Harber, M Reeves, C Magee
American Transplant Congress 2018
https://atcmeetingabstracts.com/abstract/association-between-donor-recipient-bk-viral-serostatus-and-risk-of-bk-viraemia-post-transplantation/

Unraveling the neuroimmunological pathways surrounding brain death: Systematic study of clinically relevant serum biomarker changes during donor management from admission to procurement
K Bera, M Lo Faro, H Huang, S Maslau, R Ploeg
American Transplant Congress 2018
https://atcmeetingabstracts.com/abstract/unraveling-the-neuroimmunological-pathways-surrounding-brain-death-systematic-study-of-clinically-relevant-serum-biomarker-changes-during-donor-management-from-admission-to-procurement/

Donor management as window of opportunity: understanding serum marker changes with duration of brain death
Katarzyna D Bera, M Letizia Lo Faro, Sergei Maslau, Joel Tabak-Sznajder, Rutger J Ploeg
British Transplant Society 2019
https://bts.org.uk/wp-content/uploads/2019/03/BTS-NHSBT-Abstract-Book-2019-FINAL.pdf

Unravelling mechanisms of delayed graft function and recovery in DCD kidney transplantation
Letizia Lo Faro, Kaithlyn Rozenberg, Honglei Huang, Sergei Maslau, Henri Leuvenink, Edward Sharples, Rutger Ploeg
British Transplant Society 2019
https://bts.org.uk/wp-content/uploads/2019/03/BTS-NHSBT-Abstract-Book-2019-FINAL.pdf

Identification of exosome proteins associated with transplant outcome from donor plasma
Adam Thorne, Honglei Huang, Benedikt Kessler, Rutger Ploeg
British Transplant Society 2019
https://bts.org.uk/wp-content/uploads/2019/03/BTS-NHSBT-Abstract-Book-2019-FINAL.pdf

Donor management in donation after brain death: A window of opportunity—are pro-inflammatory mediators the target and what is the effect of duration of brain death?
K D Bera, J Tabak, M L Lo Faro, R J Ploeg
American Transplant Congress 2019
https://atcmeetingabstracts.com/abstract/donor-management-in-donation-after-brain-death-a-window-of-opportunity-are-pro-inflammatory-mediators-the-target-and-what-is-the-effect-of-duration-of-brain-death/

Donation after circulatory death kidneys with prolonged delayed graft function present widespread metabolic and translational deficiencies at time of retrieval
M L Lo Faro, K Rozenberg, H Huang, S Maslau, H Leuvenink, E Sharples, R Ploeg
American Transplant Congress 2019
https://atcmeetingabstracts.com/abstract/donation-after-circulatory-death-kidneys-with-prolonged-delayed-graft-function-present-widespread-metabolic-and-translational-deficiencies-at-time-of-retrieval/

Transmission electron microscopy analysis of stress induced changes during pancreas preservation
N. Kattner, D. Tiniakos, Y. Bury, K. White, T. Davey, L. Eliasson, L. Tindale, B. Wagner, M. Honkanen-Scott, N. Dyson, K. Dalgarno, A. Ferreira-Duarte, R. Ploeg, J. Shaw, W. Scott
2019 World Congress of the International Pancreas and Islet Transplant Association (IPITA)
http://www.ipita2019.org/programme-scientifique

Establishing a whole pancreas biopsy collection protocol for the Quality in Organ Donation (QUOD) Biobank
M. Honkanen-Scott, M. Bourne, J. Doyle, N. Dyson, Y. Bury, D. Tiniakos, R. Ploeg, W. Scott, J. Shaw.
2019 World Congress of the International Pancreas and Islet Transplant Association (IPITA)
http://www.ipita2019.org/programme-scientifique

Profibrotic TGF-B In Deceased Donor Kidneys Regulates Catabolic Pathways and Long-term Function After Transplantation
Rebecca Vaughan, Louise Farmer, Gavin Welsh, Rikke Norregaard, Benedikt Kessler, Rutger Ploeg, Maria Kaisar
2019 Congress of the European Society for Organ Transplantation
https://onlinelibrary.wiley.com/doi/epdf/10.1111/tri.13507